The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2011
Filed:
Mar. 01, 2006
Applicant:
Nina Herne, Stockholm, SE;
Inventor:
Nina Herne, Stockholm, SE;
Assignee:
Affibody AB, Bromma, SE;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01); C12N 15/00 (2006.01); C12N 5/00 (2006.01); C07H 21/00 (2006.01); C07K 14/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
A TNF-α binding polypeptide is provided, which is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having 1 to about 20 substitution mutations. Nucleic acid encoding the polypeptide, expression vector comprising the nucleic acid, and host cell comprising the expression vector are also provided. Also provided are methods comprising a step of affinity separation or detection, in which step a polypeptide according to the invention is used. Such methods may be used for reducing the content of TNF-α in a body fluid.