The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2011
Filed:
Jun. 30, 2004
Jörgen Carlsson, Uppsala, SE;
Stefan Ståhl, Stockholm, SE;
Tove Eriksson, Stockholm, SE;
Elin Gunneriusson, Lidingö, SE;
Fredrik Nilsson, Stockholm, DE;
Jörgen Carlsson, Uppsala, SE;
Stefan Ståhl, Stockholm, SE;
Tove Eriksson, Stockholm, SE;
Elin Gunneriusson, Lidingö, SE;
Fredrik Nilsson, Stockholm, DE;
Affibody AB, Bromma, SE;
Abstract
A polypeptide is provided, which has a binding affinity for HER2 and which is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having from 1 to about 20 substitution mutations. Nucleic acid encoding the polypeptide, as well as expression vector and host cell for expressing the nucleic acid, are also provided. Also provided is the use of such a polypeptide as a medicament, and as a targeting agent for directing substances conjugated thereto to cells overexpressing HER2. Methods, and kits for performing the methods, are also provided, which methods and kits rely on the binding of the polypeptide to HER2.