The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2011
Filed:
Apr. 26, 2007
Applicants:
Yuko Kobayashi, Kanagawa, JP;
Hiroyuki Tsuji, Kanagawa, JP;
Masafumi Kamada, Kanagawa, JP;
Tatsuya Sawamura, Kyoto, JP;
Inventors:
Yuko Kobayashi, Kanagawa, JP;
Hiroyuki Tsuji, Kanagawa, JP;
Masafumi Kamada, Kanagawa, JP;
Tatsuya Sawamura, Kyoto, JP;
Assignee:
Amgen Fremont, Inc., Fremont, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
Abstract
Various human monoclonal antibodies that bind to human LOX-1 and inhibit the binding of in-vivo LOX-1 ligands to LOX-1, and the LOX-1-mediated incorporation of the ligands into cells, were obtained by immunizing human antibody-producing transgenic mice (created by genetic engineering) with soluble human oxidized LDL receptor (LOX-1). Furthermore, the human monoclonal antibodies were found to be effective in preventing and treating a variety of diseases.