The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 26, 2011
Filed:
May. 10, 2007
Robert G. Griffin, Newton, MA (US);
Kan-nian HU, Silver Spring, MD (US);
Timothy M. Swager, Newton, MA (US);
Changsik Song, Brighton, MA (US);
Eric Dane, Somerville, MA (US);
Robert G. Griffin, Newton, MA (US);
Kan-Nian Hu, Silver Spring, MD (US);
Timothy M. Swager, Newton, MA (US);
Changsik Song, Brighton, MA (US);
Eric Dane, Somerville, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The present invention provides methods for performing dynamic nuclear polarization using biradicals with a structure of formula (I) as described herein. In general, the methods involve (a) providing a frozen sample in a magnetic field, wherein the frozen sample includes a biradical of formula (I) and an analyte with at least one spin half nucleus; (b) polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation having a frequency that excites electron spin transitions in the biradical; (c) optionally melting the sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the frozen or molten sample. The present invention also provides biradicals with a structure of formula (I) with the proviso that Qand Qare different when Xand Xare —O—. The present invention also provides methods for making biradicals with a structure of formula (IA) as described herein.