The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 26, 2011
Filed:
Feb. 09, 2007
Applicants:
Eisaku Yoshihara, Kanagawa, JP;
Hidatoshi Inoko, Kanagawa, JP;
Inventors:
Eisaku Yoshihara, Kanagawa, JP;
Hidatoshi Inoko, Kanagawa, JP;
Assignee:
Tokai University, Kanagawa, JP;
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/40 (2006.01);
U.S. Cl.
CPC ...
Abstract
The purpose of the present invention is to provide a method and an agent to efficiently inhibit the function of the drug efflux pump of. The invention provides a method to inhibit the function of the drug efflux pump of, comprising modifying any amino acid residue selected from 100th to 109th or 311th to 320th amino acid residues in the amino acid sequence of mature OprM protein. The invention also provides an agent having such inhibitory effect, and a screening method thereof.