The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 19, 2011
Filed:
Jul. 16, 2007
Jin Zhang, Baltimore, MD (US);
Bharath Ananthanarayanan, Scotch Plains, NJ (US);
Jin Zhang, Baltimore, MD (US);
Bharath Ananthanarayanan, Scotch Plains, NJ (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
Nucleic acid molecules encoding emission ratiometric indicators of phosphoinositides, which comprise a fusion protein comprising a pleckstrin homology (PH) domain of Akt (also known as protein kinase B) and a 'pseudoligand' containing acidic amino acid residues, which is sandwiched between resonance energy transfer (RET) pairs, such as cyan and yellow mutants of GFP (a FRET pair). The nucleic acid molecules can be used, for example, to produce the indicators which can be used, inter alia, to monitor spatiotemporal dynamics of phosphoinositides and in high throughput assays for inhibitors of PI3K, including drug screening assays.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile