The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 19, 2011
Filed:
Nov. 10, 2006
Györgyi Kovanyine Lax, Budapest, HU;
Gábor Nemeth, Budapest, HU;
György Krasznay, Budapest, HU;
Norbert Mesterhazy, Szombathely, HU;
Kálmán Nagy, Budapest, HU;
Györgyi Vereczkeyné Donáth, Budapest, HU;
Zsuzsanna Szent-kirallyi, Budapest, HU;
Györgyi Kovanyine Lax, Budapest, HU;
Gábor Nemeth, Budapest, HU;
György Krasznay, Budapest, HU;
Norbert Mesterhazy, Szombathely, HU;
Kálmán Nagy, Budapest, HU;
Györgyi Vereczkeyné Donáth, Budapest, HU;
Zsuzsanna Szent-Kirallyi, Budapest, HU;
Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag, Budapest, HU;
Abstract
The invention relates to a process for the preparation of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno-[2,3-b][1,5]benzodiazepine (olanzapine) of the formula (I) by reacting 4-amino-2-methyl-10H-thieno[2,3-b][1/5]benzodiazepine hydrochloride of the formula (II) with N-methylpiperazine in an organic solvent, which comprises carrying out the reaction in the mixture of toluene and 1,3-dimethyl-2-imidazolidinone. The invention also encompasses new 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b] [1,5]benzodiazepine dihydrochloride trihydrate of the formula (IB), the preparation thereof and pharmaceutical compositions comprising said new compound.