The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 19, 2011
Filed:
Jun. 21, 2002
David Weiner, Del Mar, CA (US);
Tim Hitchman, San Diego, CA (US);
Lishan Zhao, Carlsbad, CA (US);
Mark J. Burk, San Diego, CA (US);
Grace Desantis, San Diego, CA (US);
Sarah Richardson Hanson, San Diego, CA (US);
Aileen Milan, San Diego, CA (US);
Toby Richardson, San Diego, CA (US);
Patti Kretz, San Marcos, CA (US);
William Greenberg, San Diego, CA (US);
David Weiner, Del Mar, CA (US);
Tim Hitchman, San Diego, CA (US);
Lishan Zhao, Carlsbad, CA (US);
Mark J. Burk, San Diego, CA (US);
Grace Desantis, San Diego, CA (US);
Sarah Richardson Hanson, San Diego, CA (US);
Aileen Milan, San Diego, CA (US);
Toby Richardson, San Diego, CA (US);
Patti Kretz, San Marcos, CA (US);
William Greenberg, San Diego, CA (US);
Verenium Corporation, San Diego, CA (US);
Abstract
The invention provides biocatalytic methods for the manufacture of pure single enantiomer compounds. This invention provides methods of screening for enzymes which are highly enantioselective or enzymes that can provide any desired stereoisomer of a compound. The invention provides the use of single enantiomer substrates in performing a growth screen of a clonal library to identify highly stereoselective enzymes. In one aspect, methods for screening and identification of enzymes, e.g., transaminases, nitrilases, aldolases, epoxide hydrolases are provided. Methods for the production and screening of gene libraries generated from nucleic acids isolated from more than one organism for enzyme, e.g., transaminase, activities are also provided.