The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 19, 2011
Filed:
Apr. 10, 2009
Denong Wang, Palo Alto, CA (US);
Leonore A. Herzenberg, Stanford, CA (US);
Donna M. Peehl, Mountain View, CA (US);
Leonard A. Herzenberg, Palo Alto, CA (US);
Denong Wang, Palo Alto, CA (US);
Leonore A. Herzenberg, Stanford, CA (US);
Donna M. Peehl, Mountain View, CA (US);
Leonard A. Herzenberg, Palo Alto, CA (US);
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Abstract
Disclosed are methods for probing the immunogenic sugar moieties of prostate cancer cells. The methods detect a number of glyco-epitopes that are highly and differentially expressed among prostate cancers of various Gleason grades. The glyco-epitopes exist on the surfaces of prostate cells. The methods also comprise the detection of autoantibodies in prostate cancer subjects. The antibodies bound to a glyco-motif of N-glycans that is normally 'cryptic.' This target is highly expressed in prostate cancers. Lectins and antibodies that detect these glyco-epitopes that expressed in prostate cancer tissues includelectin (EEL);Lectin-I (PTL-I);Lectin-I-A4 (GSL-I-A4);Lectin-I-B4 (GSL-I-B4);I agglutinin (SNA-I;-L (PHA-L;agglutinin (GNA);agglutinin (NPA);agglutinin (Jacalin); and mAb TM10 (IgM).