The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 12, 2011
Filed:
Nov. 03, 2006
Kristin H. Jarman, Richland, WA (US);
William R. Cannon, Richland, WA (US);
Kenneth D. Jarman, Richland, WA (US);
Alejandro Heredia-langner, Richland, WA (US);
Kristin H. Jarman, Richland, WA (US);
William R. Cannon, Richland, WA (US);
Kenneth D. Jarman, Richland, WA (US);
Alejandro Heredia-Langner, Richland, WA (US);
Battelle Memorial Institute, Richland, WA (US);
Abstract
Peptides are identified from a list of candidates using collision-induced dissociation tandem mass spectrometry data. A probabilistic model for the occurrence of spectral peaks corresponding to frequently observed partial peptide fragment ions is applied. As part of the identification procedure, a probability score is produced that indicates the likelihood of any given candidate being the correct match. The statistical significance of the score is known without necessarily having reference to the actual identity of the peptide. In one form of the invention, a genetic algorithm is applied to candidate peptides using an objective function that takes into account the number of shifted peaks appearing in the candidate spectrum relative to the test spectrum.