The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 12, 2011
Filed:
Jul. 15, 2010
Thomas Lee Collier, Perkasie, PA (US);
Brian A. Duclos, Kalamazoo, MI (US);
Umesh B. Gangadharmath, Los Angeles, CA (US);
Zhiyong Gao, Wynnewood, PA (US);
Farhad Karimi, Mansfield, MA (US);
Dhanalakshmi Kasi, Los Angeles, CA (US);
Hartmuth C. Kolb, Playa Del Rey, CA (US);
Qianwa Liang, Hacienda Heights, CA (US);
Henry Clifton Padgett, Hermosa Beach, CA (US);
Joseph C. Walsh, Pacific Palisades, CA (US);
Tieming Zhao, Los Angeles, CA (US);
Thomas Lee Collier, Perkasie, PA (US);
Brian A. Duclos, Kalamazoo, MI (US);
Umesh B. Gangadharmath, Los Angeles, CA (US);
Zhiyong Gao, Wynnewood, PA (US);
Farhad Karimi, Mansfield, MA (US);
Dhanalakshmi Kasi, Los Angeles, CA (US);
Hartmuth C. Kolb, Playa Del Rey, CA (US);
Qianwa Liang, Hacienda Heights, CA (US);
Henry Clifton Padgett, Hermosa Beach, CA (US);
Joseph C. Walsh, Pacific Palisades, CA (US);
Tieming Zhao, Los Angeles, CA (US);
Siemens Medical Solutions USA, Inc., Malvern, PA (US);
Abstract
The present invention relates to novel radioactively labeled bioreducible tracers of Formula I useful for detecting hypoxic tumors or ischemic tissue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moiety, a triazole, metabolically stable linker with pharmacokinetics enhancing substituents, and a radioisotope. The preferred in vivo imaging modality is positron emission tomography.