The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 12, 2011
Filed:
Nov. 02, 2005
Xi Jiang, Cincinnati, OH (US);
Jacques Le Pendu, Nantes, FR;
Xi Jiang, Cincinnati, OH (US);
Jacques Le Pendu, Nantes, FR;
Children's Hospital Medical Center, Cincinnati, OH (US);
INSERM, Nantes Codex, FR;
Abstract
The invention provides a compound which competitively inhibits the binding of a norovirus with a native blood antigen of a human host, as well as a kit for determining whether an individual has been infected by a norovirus. Also provided is a method for determining the susceptibility of an individual to infection by a particular, known strain of norovirus. The invention is based on the determination that noroviruses recognize human blood antigens such as human histo-blood group antigens (HBGAs) as a receptor in seven specific binding patterns. The invention allows one to predict that a particular strain of norovirus can infect humans who have a particular human histo-blood type, as well as blood antigens that can bind the particular strain of infecting norovirus. The invention also allows one to predict that a particular strain of norovirus will bind with one or more particular histo-blood group antigens, but will not bind with other blood group antigens.