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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7977049 B1

PDFFull Text
Date of Patent:
Jul. 12, 2011

Filed:

Feb. 08, 2005

Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms

Applicants:

David A. Sinclair, West Roxbury, MA (US);

Kevin J. Bitterman, Boston, MA (US);

Inventors:

David A. Sinclair, West Roxbury, MA (US);

Kevin J. Bitterman, Boston, MA (US);

Assignee:

President and Fellows of Harvard College, Cambridge, MA (US);

Attorney:

Wolf, Greenfield & Sacks, P.C.

Primary Examiner:

Yong D Pak

Int. Cl.
CPC ...
C12Q 1/68 (2006.01); C12Q 1/00 (2006.01); C12N 9/78 (2006.01); C12N 15/63 (2006.01); C12N 5/00 (2006.01); C12N 15/00 (2006.01); C12N 1/20 (2006.01); A01N 63/00 (2006.01); A61K 48/00 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention provides methods and compositions for modulating the life span of eukaryotic and prokaryotic cells and for protecting cells against certain stresses, e.g., heatshock. One method comprises modulating the flux of the NAD+ salvage pathway in the cell, e.g., by modulating the level or activity of one or more proteins selected from the group consisting of NPT1, PNC1, NMA1 and NMA2. Another method comprises modulating the level of nicotinamide in the cell.

Find Patent Forward Citations

Sinclair, David. (2011). Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms (U.S. Patent No. 7977049). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/7977049

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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