The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2011
Filed:
Oct. 05, 2005
Ivan Ivanov, Sofia, BG;
Rumen Tsanev, Sofia, BG;
Genoveva Nacheva, Sofia, BG;
Hans-guenther Grigoleit, Wiesbaden, DE;
Rolf Gunther, Mainz, DE;
Ivan Ivanov, Sofia, BG;
Rumen Tsanev, Sofia, BG;
Genoveva Nacheva, Sofia, BG;
Hans-Guenther Grigoleit, Wiesbaden, DE;
Rolf Gunther, Mainz, DE;
Other;
Abstract
The invention relates to an inhibitor of endogenous human interferon-gamma (hIFN-ϝ) in autoimmune diseases, especially in multiple sclerosis. More precisely, the invention relates to inactivated protein derivatives of the hIFN-ϝ with preserved affinity to the hIFN-ϝ receptor. The derivatives represent genetically modified variants of hIFN-ϝ where the C-terminal part of the molecule is either deleted or replaced with a polypeptide sequence of another human protein and a recombinant hIFN-ϝ inactivated by physical or chemical methods.