The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2011
Filed:
Mar. 31, 2005
James William Leahy, San Leandro, CA (US);
Gary Lee Lewis, San Francisco, CA (US);
John M. Nuss, Danville, CA (US);
Brain Hugh Ridgway, Belmont, CA (US);
Joan C. Sangalang, Mountain View, CA (US);
James William Leahy, San Leandro, CA (US);
Gary Lee Lewis, San Francisco, CA (US);
John M. Nuss, Danville, CA (US);
Brain Hugh Ridgway, Belmont, CA (US);
Joan C. Sangalang, Mountain View, CA (US);
Exelixis, Inc., South San Francisco, CA (US);
Abstract
The present invention relates to compounds of the Formula I, wherein L, X, Y, Z, R, R, Rand Rare defined herein. The invention also provides methods of using the compounds for inhibition of kinases, more specifically ALK kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions; (Formula I).