The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2011
Filed:
Nov. 03, 2006
Applicants:
Rebecca Tempel, Portland, OR (US);
Xin-he Lai, Portland, OR (US);
Fred L. Heffron, Portland, OR (US);
Inventors:
Rebecca Tempel, Portland, OR (US);
Xin-He Lai, Portland, OR (US);
Fred L. Heffron, Portland, OR (US);
Assignee:
Oregon Health & Science University, Portland, OR (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/02 (2006.01); A61K 48/00 (2006.01); C12N 1/20 (2006.01); A01N 63/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
is the bacterial pathogen that causes tularemia in humans and a number of animals. To date, no approved vaccine exists for this widespread and life-threatening disease. The present disclosure provides attenuatedmutants that include functional deletions in one or more of the dsbB, FTT0742, pdpB, fumA, and carB genes. Also provided are immunogenic compositions that include the attenuated bacteria. Methods are provided for treatment using the attenuatedmutants.