The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2011
Filed:
Aug. 27, 2010
Mark D. Cochran, Carlsbad, CA (US);
Gary R. Peterson, Omaha, NE (US);
Stephen V. Lair, Temecula, CA (US);
Richard M. Synenki, San Diego, CA (US);
Mark D. Cochran, Carlsbad, CA (US);
Gary R. Peterson, Omaha, NE (US);
Stephen V. Lair, Temecula, CA (US);
Richard M. Synenki, San Diego, CA (US);
Intervet Inc., Summit, NJ (US);
Abstract
The present invention discloses attenuatedorganisms that express a substantially nontoxic alpha-toxin. The expressed alpha-toxin is a deletion mutein that relative to the alpha-toxin of the mature alpha-toxin ofstrain 13, is missing at least nine consecutive amino acid residues including His. The present invention also discloses attenuated organisms that encode the muteins, as well as the use of such attenuated organisms as vaccines.