The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2011
Filed:
Jul. 03, 2009
Shunji Tomatsu, Saint Louis, MO (US);
Adriana Montaño-suarez, Saint Louis, MO (US);
Carlos J. Alméciga-diaz, Bogoté D.C., CO;
Luis Barrera, Bogoté D.C., CO;
Shunji Tomatsu, Saint Louis, MO (US);
Adriana Montaño-Suarez, Saint Louis, MO (US);
Carlos J. Alméciga-Diaz, Bogoté D.C., CO;
Luis Barrera, Bogoté D.C., CO;
Saint Louis University, Saint Louis, MO (US);
Abstract
This invention relates to compositions and methods of delivering therapeutic agents to bone. More specifically, the invention relates to endowing a large molecule vectors i.e., adeno virus, retrovirus, liposomes, micelles, natural and synthetic polymers, or combinations thereof, with the ability to target bone tissue in vivo and with improved stability in the blood, by attaching multiple copies of acid amino acid peptides. One preferred embodiment of the invention relates to endowing an adeno-associated virus (AAV) vector with the ability to target bone-tissue in vivo and improve its stability, by the addition of multiple acidic amino acid peptides attached to the capsid of the viral vector.