The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 05, 2011
Filed:
May. 11, 2010
Jeffery Dove, Santa Ana, CA (US);
Darin Dobler, Aliso Viejo, CA (US);
Jim Davidson, San Juan Capistrano, CA (US);
Gregory Wright, Orange, CA (US);
Jeffery Dove, Santa Ana, CA (US);
Darin Dobler, Aliso Viejo, CA (US);
Jim Davidson, San Juan Capistrano, CA (US);
Gregory Wright, Orange, CA (US);
Edwards Lifesciences Corporation, Irvine, CA (US);
Abstract
A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to inhibit oxidation in dehydrated tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the oxidation and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. In one method, tissue leaflets in assembled bioprosthetic heart valves are pretreated with an aldehyde capping agent prior to dehydration and sterilization.