The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2011
Filed:
Jul. 06, 2007
Sui Xiong Cai, San Diego, CA (US);
John A. Drewe, Carlsbad, CA (US);
Shailaja Kasibhatla, San Diego, CA (US);
William D. Kemnitzer, San Diego, CA (US);
Ben Y. Tseng, San Diego, CA (US);
Charles Blais, Beaconsfield, CA;
Denis Labrecque, Laval, CA;
Henriette Gourdeau, Montreal, CA;
Sui Xiong Cai, San Diego, CA (US);
John A. Drewe, Carlsbad, CA (US);
Shailaja Kasibhatla, San Diego, CA (US);
William D. Kemnitzer, San Diego, CA (US);
Ben Y. Tseng, San Diego, CA (US);
Charles Blais, Beaconsfield, CA;
Denis Labrecque, Laval, CA;
Henriette Gourdeau, Montreal, CA;
Cytovia, Inc., Tarrytown, NY (US);
Abstract
The present invention is directed to a substituted 4H-chromene represented by the Formula 1R, substantially free from the corresponding (S)-stereoisomer: The present invention also relates to the discovery that compound 1R, substantially free from the corresponding (S)-stereoisomer, is an activator of caspases and inducer of apoptosis, as well as an antivascular agent. Therefore, compound 1R, substantially free from the corresponding (S)-stereoisomer, can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs. Compound 1R, substantially free from the corresponding (S)-stereoisomer, also can be used for the treatment of diseases due to overgrowth of vasculature, such as solid tumors and ocular neovascularization.