The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2011
Filed:
Jan. 02, 2008
Timothy J. Deming, Summerland, CA (US);
Miaoer Yu, San Jose, CA (US);
Scott A. Curtin, Santa Barbara, CA (US);
Jungyeon Hwang, Goleta, CA (US);
Michael D. Wyrsta, Goleta, CA (US);
Andrew Nowak, Goleta, CA (US);
Scott W. Seidel, Goleta, CA (US);
Timothy J. Deming, Summerland, CA (US);
Miaoer Yu, San Jose, CA (US);
Scott A. Curtin, Santa Barbara, CA (US);
Jungyeon Hwang, Goleta, CA (US);
Michael D. Wyrsta, Goleta, CA (US);
Andrew Nowak, Goleta, CA (US);
Scott W. Seidel, Goleta, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amido-containing metallacycle, for making self assembling amphiphilic block copolypeptides and related protocols for adding oligo(ethyleneglycol) functionalized aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex to forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.