The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2011
Filed:
Jun. 23, 2006
Yusuke Nakamura, Bunkyo-ku, JP;
Yoichi Furukawa, Bunkyo-ku, JP;
Ryuji Hamamoto, Bunkyo-ku, JP;
Shuichi Nakatsuru, Kawasaki, JP;
Yusuke Nakamura, Bunkyo-ku, JP;
Yoichi Furukawa, Bunkyo-ku, JP;
Ryuji Hamamoto, Bunkyo-ku, JP;
Shuichi Nakatsuru, Kawasaki, JP;
Oncotherapy Science, Inc., Kanagawa, JP;
Abstract
The present invention features a method for determining the methyltransferase activity of a polypeptide and screening for modulators of methyltransferase activity, more particularly for modulators of the methylation of retinoblastoma by SMYD3. The invention further provides a method or pharmaceutical composition for prevention or treating of colorectal cancer, hepatocellular carcinoma, bladder cancer and/or breast cancer using a modulator so identified. N-terminal truncated forms of SMYD3 (alias ZNFN3A1) have higher methylating activity. Lys 824 is a preferred methylation site on the RB1 protein for SMYD3.