The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2011
Filed:
Feb. 16, 2006
Clifford J. Woolf, Newton, MA (US);
Tarek A. Samad, Princeton, NJ (US);
Herbert Y. Lin, Watertown, MA (US);
Jodie Babitt, Newton, MA (US);
Raymond T. Chung, Chestnut Hill, MA (US);
Alan L. Schneyer, Concord, MA (US);
Clifford J. Woolf, Newton, MA (US);
Tarek A. Samad, Princeton, NJ (US);
Herbert Y. Lin, Watertown, MA (US);
Jodie Babitt, Newton, MA (US);
Raymond T. Chung, Chestnut Hill, MA (US);
Alan L. Schneyer, Concord, MA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.