The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2011
Filed:
Nov. 27, 2006
Herren Wu, Boyds, MD (US);
Changshou Gao, Potomac, MD (US);
Ling-ling an, Boyds, MD (US);
Peter Kiener, Potomac, MD (US);
Su-yau Mao, Gaithersburg, MD (US);
Anthony Coyle, Washington, DC (US);
Jane Tian, North Potomac, MD (US);
Herren Wu, Boyds, MD (US);
Changshou Gao, Potomac, MD (US);
Ling-Ling An, Boyds, MD (US);
Peter Kiener, Potomac, MD (US);
Su-Yau Mao, Gaithersburg, MD (US);
Anthony Coyle, Washington, DC (US);
Jane Tian, North Potomac, MD (US);
MedImmune, LLC, Gaithersburg, MD (US);
Abstract
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise, for example, high affinity antibodies that specifically bind HMG1 and antigenic fragments thereof. The high affinity antibodies of the present invention and pharmaceutical compositions comprising the same are useful for many purposes, for example, as therapeutics against a wide range of inflammatory diseases and disorders such as sepsis, rheumatoid arthritis, peritonitis, Crohn s disease, reperfusion injury, septicemia, endotoxic shock, cystic fibrosis, endocarditis, psoriasis, psoriatic arthritis, arthritis, anaphylactic shock, organ ischemia, reperfusion injury, and allograft rejection. In addition, the high affinity antibodies of the present inventions are useful as diagnostic antibodies.