The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2011
Filed:
Sep. 06, 2007
James J. D. Hsieh, Ladue, MO (US);
Stanley J. Korsmeyer, Weston, MA (US);
Susan Korsmeyer, Legal Representative, Weston, MA (US);
Emily H. Y. Cheng, Ladue, MO (US);
James J. D. Hsieh, Ladue, MO (US);
Stanley J. Korsmeyer, Weston, MA (US);
Susan Korsmeyer, legal representative, Weston, MA (US);
Emily H. Y. Cheng, Ladue, MO (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Abstract
A novel protease, Taspase1, is described. Taspase1 is involved in the cleavage of the myeloid/lymphoid or mixed-lineage leukemia (i.e., MLL) protein, which is required for proper HOX gene regulation. Diagnostic methods utilizing Taspase1 are provided, as well as inhibitors of Taspase1. Methods of using the inhibitors of Taspase1 are also described. For example an inhibitor of Taspase1 can be used to treat a cancer, e.g., leukemia, in a subject.