Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the β2 adrenergic receptor

Abstract

A compound of formula (I) or a pharmaceutically-acceptable salt, solvate or stereoisomer thereof wherein Ris a group chosen from —CHOH and —NHC(O)H; Ris a hydrogen atom or Rtogether with Rform the group —NH—C(O)—CH═CH—, wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding Rand the carbon atom is bound to the carbon atom in the phenyl ring holding R; Ris chosen from a hydrogen atom, a halogen atom and groups chosen from —SO—R, —SO—R, —NH—CO—NH, —CO—NH, hydantoino, Calkyl, Calkoxy and —SONRR; Ris chosen from a hydrogen atom, a halogen atom and a Calkyl group; Ris chosen from a Calkyl group and a Ccycloalkyl group; Ris independently chosen from a hydrogen atom and a Calkyl group; n, p and q are independently 0, 1, 2, 3 or 4; m and s are independently 0, 1, 2 or 3; and r is 0, 1 or 2 with the provisos that at least one of m and r is not 0, the sum n+m+p+q+r+s is 7, 8, 9, 10, 11, 12 or 13, and the sum q+r+s is 2, 3, 4, 5 or 6.