The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2011
Filed:
Mar. 12, 2004
Mark Kelly, San Francisco, CA (US);
Hugo Villar, San Diego, CA (US);
Jianqiang Wang, Acton, MA (US);
Min S. Lee, Madison, WI (US);
Yong Qin, Chengdu, CN;
Daniel S. Sem, New Berlin, WI (US);
Mark Kelly, San Francisco, CA (US);
Hugo Villar, San Diego, CA (US);
Jianqiang Wang, Acton, MA (US);
Min S. Lee, Madison, WI (US);
Yong Qin, Chengdu, CN;
Daniel S. Sem, New Berlin, WI (US);
Triad Liquidating Company, LLC, Rancho Santa Fe, CA (US);
Abstract
The invention provides a method for identifying a ligand that binds to a macromolecular target. The methods involve (a) attaching an antenna moiety to a first ligand, wherein the ligand binds specifically to a macromolecular target; (b) providing a sample comprising the macromolecular target, the first ligand and a candidate second ligand under conditions wherein the first ligand and the macromolecular target form a bound complex; (c) detecting a subset of magnetization transfer signals between the antenna moiety of the first ligand and the second candidate ligand, wherein the signals are obtained from an isotope edited NOESY spectrum of the sample; thereby determining that the two ligands are proximal in a bound complex, and identifying a second ligand that binds to the macromolecular target.