The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2011
Filed:
Aug. 28, 2008
Paul Chaplin, Munich, DE;
Paul Howley, Berwick, AU;
Christine Meisinger-henschel, Neuried, DE;
Ingmar Rathe, Olching, DE;
Eva Felder, Munich, DE;
Karl Heller, Unterfohring, DE;
Paul Chaplin, Munich, DE;
Paul Howley, Berwick, AU;
Christine Meisinger-Henschel, Neuried, DE;
Ingmar Rathe, Olching, DE;
Eva Felder, Munich, DE;
Karl Heller, Unterfohring, DE;
Bavarian Nordic A/S, Kvistgaard, DK;
Abstract
The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus and the use of the virus, or its recombinants, as a medicament or vaccine. A method is provided for inducing an immune response in individuals who may be immune-compromised, receiving antiviral therapy, or have a pre-existing immunity to the vaccine virus. In addition, a method is provided for the administration of a therapeutically effective amount of the virus, or its recombinants, in a vaccinia virus prime/vaccinia virus boost inoculation regimen. The present invention relates to a method of virus amplification in primary cells which are cultivated in a serum free medium. Viruses produced by this method are advantageously free of any infectious agents comprised in animal sera.