The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 21, 2011
Filed:
Feb. 28, 2003
Reinhard Ebner, Gaithersburg, MD (US);
Guo-liang Yu, Berkeley, CA (US);
Steven M Ruben, Brookeville, MD (US);
Yifan Zhai, Rockville, MD (US);
Stephen Ullrich, Rockville, MD (US);
Reinhard Ebner, Gaithersburg, MD (US);
Guo-Liang Yu, Berkeley, CA (US);
Steven M Ruben, Brookeville, MD (US);
Yifan Zhai, Rockville, MD (US);
Stephen Ullrich, Rockville, MD (US);
Human Genome Sciences, Inc., Rockville, MD (US);
Abstract
The present invention relates to a novel member of the TNF-Ligand superfamily. More specifically, isolated nucleic acid molecules are provided encoding a human Apoptosis Inducing Molecule II (AIM II). AIM II polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of AIM II activity. Also provided are therapeutic methods for treating lymphadenopathy, aberrant bone development, autoimmune and other immune system diseases, graft versus host disease, rheumatoid arthritis, osteoarthritis and to inhibit neoplasia, such as tumor cell growth.