The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2011
Filed:
Oct. 27, 2004
Aimee L. Jackson, Seattle, WA (US);
Steven R. Bartz, Seattle, WA (US);
Julja Burchard, Mount Vernon, WA (US);
Peter S. Linsley, Seattle, WA (US);
Wei GE, Redmond, WA (US);
Guy L. Cavet, Burlingame, CA (US);
Aimee L. Jackson, Seattle, WA (US);
Steven R. Bartz, Seattle, WA (US);
Julja Burchard, Mount Vernon, WA (US);
Peter S. Linsley, Seattle, WA (US);
Wei Ge, Redmond, WA (US);
Guy L. Cavet, Burlingame, CA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity.