The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2011
Filed:
Jun. 19, 2007
Robert L. Raffai, Half Moon Bay, CA (US);
Karl Weisgraber, Walnut Creek, CA (US);
Robert L. Raffai, Half Moon Bay, CA (US);
Karl Weisgraber, Walnut Creek, CA (US);
The J. David Gladstone Institutes, Irvine, CA (US);
The Regents of the University of California, Oakland, CA (US);
The United States of America as represented by the Department of Veterans Affairs, Washington, DC (US);
Abstract
An animal model has been developed where the animals can survive myocardial infarctions caused by diet-induced coronary atherosclerosis, and live with chronic heart failure. This animal model is a result of reduced activity of scavenger receptor class BI (SR-BI) and ApoE and the inducible activity of the Mx1-Cre gene. In a preferred embodiment, the model is a result of crossbreeding two transgenic mouse lines: a knockout of SR-BI (SRBI) and an impaired ApoE expressor (Apoe) to generate a strain referred to as ApoeSRB1mice, which is then crossbred to mice that carry the inducible Mx1-Cre transgene. The ApoeSRB1mouse model is genetically modified, enabling the offspring to rapidly and permanently lower their high blood cholesterol levels caused by dietary challenge. The ability to rapidly and permanently lower blood cholesterol levels in these mice stops and may cause the regression of occlusive coronary atherosclerosis restoring blood flow to the heart, allowing the mice to survive from myocardial infarction and live with chronic heart failure.