Pharmaceutical intermediate for synthesizing ace inhibitors and the use thereof

Abstract

The compounds of the general Formula (I), wherein Ris aryl or alkyl; Rrepresents alkyl; Rrepresents alkyl or aralkyl, are valuable pharmaceutical intermediates, which can be prepared by reacting a compound of the general Formula (IV) (wherein the definitions of Rand Rare as above), with at least 2 molar equivalents of the compound of the general Formula (VI) (wherein X represents halogen or tertiary butyloxycarbonyloxy group and Ris as defined above). The known compounds of the general Formula (II) (wherein Rand Rare as defined above) are prepared by reacting the compounds of the general Formula (I) with thionyl chloride. The compounds of the general Formula (I) are new intermediates useful in the synthesis of pharmaceutically active ingredients, particularly in the preparation of ACE-inhibitors, e.g. enalapril, perindopril or ramipril.