The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2011
Filed:
Jan. 25, 2007
Juergen Schroeder, Mainz, DE;
Georg Dziewas, Urbar, DE;
Thomas Fachinger, Niederheimbach, DE;
Burkhard Jaeger, Bingen, DE;
Carsten Reichel, Rheinboellen, DE;
Svenja Renner, Eckenroth, DE;
Juergen Schroeder, Mainz, DE;
Georg Dziewas, Urbar, DE;
Thomas Fachinger, Niederheimbach, DE;
Burkhard Jaeger, Bingen, DE;
Carsten Reichel, Rheinboellen, DE;
Svenja Renner, Eckenroth, DE;
Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;
Abstract
The invention relates to an improved process for preparing aminocrotonylamino-substituted quinazoline derivatives of general formula (I) wherein the groups R, R, Rand Rhave the meanings given in the claims, as well as sulphonyl derivatives of formula (XIII) and the use thereof as synthesis components for preparing quinazolines of formula (I). The quinazoline derivatives of formula (I) are inhibitors of signal transduction mediated by tyrosinekinases and by the Epidermal Growth Factor-Receptor (EGF-R) and are therefore particularly suitable for the treatment of tumoral diseases.