The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2011
Filed:
Nov. 16, 2009
Edwin W. Ades, Atlanta, GA (US);
George M. Carlone, Stone Mountain, GA (US);
Barun K. DE, Snellville, GA (US);
Jacquelyn S. Sampson, College Park, GA (US);
Robert C. Huebner, Stroudsburg, PA (US);
Edwin W. Ades, Atlanta, GA (US);
George M. Carlone, Stone Mountain, GA (US);
Barun K. De, Snellville, GA (US);
Jacquelyn S. Sampson, College Park, GA (US);
Robert C. Huebner, Stroudsburg, PA (US);
Abstract
The present invention relates to recombinant lipidated PsaA proteins and recombinant constructs from which such lipidated PsaA proteins may be expressed. The invention relates further to lipidated PsaA proteins in which lipidation is effected by the use of a heterologous leader sequence derived from the ospA gene of, which leader sequence is joined in translational reading frame with the psaA structural gene. The invention also provides methods of preparation of lipidated PsaA proteins and use of such proteins in immunological compositions. Also provided are vaccines comprising immunogenic lipidated PsaA proteins and methods of use of such vaccines in the prevention and treatment ofinfection.