The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 14, 2011

Filed:

Sep. 06, 2005
Applicants:

Makoto Jitsuoka, Moriya, JP;

Norikazu Ohtake, Tsukuba, JP;

Nagaaki Sato, Tsukuba, JP;

Shigeru Tokita, Tsukuba, JP;

Daisuke Tsukahara, Tsukuba, JP;

Inventors:

Makoto Jitsuoka, Moriya, JP;

Norikazu Ohtake, Tsukuba, JP;

Nagaaki Sato, Tsukuba, JP;

Shigeru Tokita, Tsukuba, JP;

Daisuke Tsukahara, Tsukuba, JP;

Assignee:

Banyu Pharmaceutical Co., Ltd., Kudankita, Chiyoda-ku, Tokyo, JP;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/44 (2006.01); A61K 31/34 (2006.01); A61K 31/335 (2006.01); C07D 401/00 (2006.01); C07D 307/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

A compound represented by, e.g. the formula (I): [wherein X, Y, Z, and W each independently represent optionally substituted methine; A, B, and D each independently represent —C(O)—, etc.; Q represents a methine or a nitrogen; and R represents the formula (II-1), optionally substituted with lower alkyl, etc.; (wherein Rrepresents a lower alkyl, etc; and Rand Reach independently represents a lower alkyl, etc.)] or a pharmaceutically acceptable salt of the compound. The compounds and salt have antagonistic activity against a histamine H3 receptor or inverse agonistic activity against a histamine H3 receptor. They are useful in the prevention or treatment of metabolic diseases, circulatory diseases, or neurotic diseases.


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