The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2011
Filed:
Dec. 19, 2006
Niall Morton Hamilton, Newhouse, GB;
Simon James Anthony Grove, Newhouse, GB;
Michael John Kiczun, Newhouse, GB;
John Richard Morphy, Newhouse, GB;
Brad Sherborne, Newhouse, GB;
Peter Thomas Albert Littlewood, Newhouse, GB;
Angus Richard Brown, Newhouse, GB;
Celia Kingsbury, Cream Ridge, NJ (US);
Michael Ohhlmeyer, Plainsboro, NJ (US);
Koc-kan Ho, West Windsor, NJ (US);
Steven G. Kultgen, Dayton, NJ (US);
Niall Morton Hamilton, Newhouse, GB;
Simon James Anthony Grove, Newhouse, GB;
Michael John Kiczun, Newhouse, GB;
John Richard Morphy, Newhouse, GB;
Brad Sherborne, Newhouse, GB;
Peter Thomas Albert Littlewood, Newhouse, GB;
Angus Richard Brown, Newhouse, GB;
Celia Kingsbury, Cream Ridge, NJ (US);
Michael Ohhlmeyer, Plainsboro, NJ (US);
Koc-Kan Ho, West Windsor, NJ (US);
Steven G. Kultgen, Dayton, NJ (US);
N.V. Organon, Oss, NL;
Abstract
The invention provides for compounds having the structure according to the formula I wherein: X is a carbon or nitrogen atom; Ar is phenyl or heteroaromatic ring; Ris hydrogen, halogen, CN or (1C-4C)alkyl; Ris hydrogen, halogen or optionally fluorinated (1C-3C)alkoxy; Rand Rare independently hydrogen, optionally halogenated (1C-4C)alkyl, optionally halogenated (1C-4C)alkoxy, optionally halogenated aryl(1C-4C)alkoxy, optionally halogenated (1C-4C)alkenyl or hydroxylmethyl; Ris hydrogen, halogen, optionally halogenated (1C-4C)alkoxy or optionally halogenated aryl(1C-4C)alkoxy; Ris hydrogen, benzyl, optionally substituted with one or more halogens or (1C-4C)alkyl, or Ris optionally halogenated (1C-4C)alkyl; each Rindependently is hydrogen, halogen, optionally halogenated (1C-4C)alkyl or optionally halogenated (1C-4C)alkoxy and pharmaceutically suitable acid addition salts thereof for use as glucocorticoid receptor modulators, in particular for treatment of central nervous system disorders.