The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 2011
Filed:
Oct. 05, 2005
Martin F. Bachmann, Seuzach, CH;
Karl G. Proba, Zürich, CH;
Patrik Maurer, Winterthur, CH;
Edwin Meijerink, Zürich, CH;
Katrin Schwarz, Schlieren, CH;
Martin F. Bachmann, Seuzach, CH;
Karl G. Proba, Zürich, CH;
Patrik Maurer, Winterthur, CH;
Edwin Meijerink, Zürich, CH;
Katrin Schwarz, Schlieren, CH;
Cytos Biotechnology AG, Zurich-Schlieren, CH;
Abstract
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising a virus-like particle (VLP) of an RNA-bacteriophage and at least one antigen, wherein the VLP is recombinantly produced in a host, and wherein the amount of host RNA with secondary structure comprised by the VLP is at most 20% of the amount of host RNA with secondary structure originally comprised by the VLP; and wherein the VLP and the at least one antigen are linked with one another. The invention also provides methods for producing the compositions of the invention. The compositions of the invention are useful in the production of vaccines for the treatment of diseases, disorders and conditions. Furthermore, the compositions of the invention are particularly useful to efficiently induce strong antibody responses against the antigen within the indicated context while lowering or eliminating unwanted T cell responses.