The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 07, 2011

Filed:

May. 08, 2003
Applicants:

Nicholas J. Ede, East Malvern, AU;

David M. Kaye, Beaumaris, AU;

Robert W. Trainor, Murrumbeena, AU;

Andrew N. Hunter, Beaumaris, AU;

Inventors:

Nicholas J. Ede, East Malvern, AU;

David M. Kaye, Beaumaris, AU;

Robert W. Trainor, Murrumbeena, AU;

Andrew N. Hunter, Beaumaris, AU;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 233/00 (2006.01); C07C 257/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

In the present specification we describe a new class of compounds, designed to modulate the ability of blood vessels to synthesize NO from L-arginine. In particular we have identified novel compounds which enhance the entry of L-arginine into cells. These compounds improve endothelial function, and thereby have the potential to retard the progression of vascular disease in conditions such as hypertension, heart failure and diabetes. This new class of drugs may also have other potentially, relevant pharmacological actions, including anti-hypertensive and anti-anginal actions.


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