The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2011
Filed:
Dec. 21, 2006
Applicants:
Guillaume Laurent Lessene, Coburg, AU;
Jonathan Baell, Ivanhoe, AU;
Inventors:
Guillaume Laurent Lessene, Coburg, AU;
Jonathan Baell, Ivanhoe, AU;
Assignee:
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, AU;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 229/00 (2006.01); A61K 31/195 (2006.01);
U.S. Cl.
CPC ...
Abstract
Benzoyl urea derivatives that are alpha helical peptides mimetics that mimic BH3-only proteins, compositions containing them, their conjugation to cell-targeting-moieties, and their use in the regulation of cell death are disclosed. The benzoyl urea derivatives are capable of binding to and neutralizing pro-survival Bcl-2 proteins. Use of benzoyl urea derivatives in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also described.