The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2011
Filed:
Jan. 11, 2010
Applicants:
Matthew During, Columbus, OH (US);
Michael Kaplitt, New York, NY (US);
Inventors:
Matthew During, Columbus, OH (US);
Michael Kaplitt, New York, NY (US);
Assignee:
Neurologix, Inc., Fort Lee, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
A01N 63/00 (2006.01); A01N 65/00 (2009.01); A61K 48/00 (2006.01); C12N 15/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding glutamic acid decarboxylase (GAD) to cells in the hippocampus, subthalamic nucleus of the basal ganglia, mesaphilia and thalamus.