The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2011
Filed:
May. 29, 2006
Applicants:
Edward Sturrock, Cape Town, ZA;
Aloysius Nchinda, Cape Town, ZA;
Kelly Chibale, Claremont, ZA;
Inventors:
Assignee:
University of Cape Town, Cape Town, ZA;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/404 (2006.01); C07D 209/20 (2006.01);
U.S. Cl.
CPC ...
Abstract
This invention relates to a process for the synthesis of ketomethylene derivatives of the tripeptide Phe-Gly-Pro ('keto-ACE', compound 5) and analogues thereof. The synthesis process proceeds via an α,β-unsaturated keto intermediate. A key feature of the process involves a Horner-Emmons olefination of the, -unsaturated keto-phosphonate with ethyl glyoxylate. Keto-ACE analogues produced by the process of the invention display C-domain selectivity.