The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2011
Filed:
Feb. 02, 2006
Stephen Critchley, Braintree, MA (US);
Thomas G. Gant, Carlsbad, CA (US);
Steven P. Langston, North Andover, MA (US);
Edward J. Olhava, Brookline, MA (US);
Stephane Peluso, Somerville, MA (US);
Stephen Critchley, Braintree, MA (US);
Thomas G. Gant, Carlsbad, CA (US);
Steven P. Langston, North Andover, MA (US);
Edward J. Olhava, Brookline, MA (US);
Stephane Peluso, Somerville, MA (US);
Millennium Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
This invention relates to compounds of formula (I-A) wherein Ring A and the variables X, Y, R, R, R, R, R, R, R, and m are defined herein. The compounds of formula (I-A) inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds of the invention are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.