The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2011
Filed:
Sep. 03, 2009
Barbara Jane Johnson, Shailer Park QLD, AU;
Andreas Suhrbier, Bunya QLD, AU;
Dean Jason Naylor, East Brisbane QLD, AU;
Caroline Amanda Dobbin, Holland Park QLD, AU;
Christopher Bruce Howard, Rochedale South QLD, AU;
Barbara Jane Johnson, Shailer Park QLD, AU;
Andreas Suhrbier, Bunya QLD, AU;
Dean Jason Naylor, East Brisbane QLD, AU;
Caroline Amanda Dobbin, Holland Park QLD, AU;
Christopher Bruce Howard, Rochedale South QLD, AU;
CBIO Limited, Eight Mile Plains, Queensland, AU;
Abstract
Methods of use of Chaperonin 10 (Cpn10) are provided for regulating Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion. Cpn10 negatively regulates Toll-like receptor agonist-induced pro-inflammatory cytokine and chemokine secretion, examples being IL-6 and RANTES, respectively. Cpn10 positively regulates Toll-like receptor agonist-induced anti-inflammatory cytokine and chemokine secretion, an example being IL-10. These immunoregulatory activities of Cpn10 may be useful in the treatment of diseases, disorders and conditions resulting from excessive pro-inflammatory cytokine and chemokine secretion. This invention also relates to producing, designing and/or screening Cpn10 agonists and antagonists according to their ability to regulate Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion.