The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2011
Filed:
Mar. 26, 2003
Shunichi Kuroda, Suita, JP;
Katsuyuki Tanizawa, Osaka, JP;
Toshihide Okajima, Ikeda, JP;
Akihiko Kondo, Kobe, JP;
Masakazu Ueda, Tokyo, JP;
Masaharu Seno, Kadotabunkamachi Okayama, JP;
Shunichi Kuroda, Suita, JP;
Katsuyuki Tanizawa, Osaka, JP;
Toshihide Okajima, Ikeda, JP;
Akihiko Kondo, Kobe, JP;
Masakazu Ueda, Tokyo, JP;
Masaharu Seno, Kadotabunkamachi Okayama, JP;
Japan Science and Technology Agency, Kawaguchi-shi, JP;
Beacle, Inc., Okayama, JP;
Abstract
The invention provides a therapeutic drug that uses hollow protein nanoparticles displaying an antibody against a specific cell or specific tissue. The effectiveness of the drug has been proved by animal testing. The invention also provides a therapeutic method using such a drug. In a drug according to the present invention, a substance to be transferred into a cell for treating a disease (for example, a cancer treating gene such as a thymidine kinase gene derived from simple herpes virus) is encapsulated in hollow nanoparticles of a particle-forming protein (for example, hepatitis B virus surface-antigen protein that has been modified to lack its infectivity to hepatocytes and display an antibody). The particle surface of the drug displays an antibody, such as a cancer specific antibody, that recognizes an antigen molecule displayed on the surface of a specific cancer cell.