The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 31, 2011
Filed:
Nov. 15, 2007
LI Gan, San Francisco, CA (US);
Lennart Mucke, San Francisco, CA (US);
Erik Roberson, Vestavia Hills, AL (US);
Sarah Mueller-steiner, Uitikon Waldegg, CH;
Li Gan, San Francisco, CA (US);
Lennart Mucke, San Francisco, CA (US);
Erik Roberson, Vestavia Hills, AL (US);
Sarah Mueller-Steiner, Uitikon Waldegg, CH;
The J. David Gladstone Institutes, San Francisco, CA (US);
Abstract
The present invention provides a method of increasing cathepsin B-induced cleavage of amyloid-β (Aβ) peptide in a cell or tissue, the method generally involving contacting the cell or tissue with an agent that increases the level of cathepsin B in the cell or tissue. The present invention further provides variant cathepsin B polypeptides that are resistant to inhibition by a cysteine protease inhibitor; as well as nucleic acids encoding the variants, and host cells comprising the nucleic acids.