The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2011
Filed:
Sep. 14, 2004
Koichi Sugita, Tokyo, JP;
Saori Kasahara, Tokyo, JP;
Hiroyasu Ebinuma, Tokyo, JP;
Humio Takaiwa, Tsukuba, JP;
Hiroshi Yasuda, Tsukuba, JP;
Takahito Jomori, Nagoya, JP;
Yuji Hayashi, Nagoya, JP;
Akira Tashita, Nagoya, JP;
Koichi Sugita, Tokyo, JP;
Saori Kasahara, Tokyo, JP;
Hiroyasu Ebinuma, Tokyo, JP;
Humio Takaiwa, Tsukuba, JP;
Hiroshi Yasuda, Tsukuba, JP;
Takahito Jomori, Nagoya, JP;
Yuji Hayashi, Nagoya, JP;
Akira Tashita, Nagoya, JP;
Nippon Paper Industries Co., Ltd., Tokyo, JP;
Sanwa Kagaku Kenkyusho Co., Ltd., Aichi, JP;
Abstract
The present invention is regarding plants and plant storage organs thereof in which GLP-1 derivatives are accumulated, and methods of producing them. The transgenic plants and plant storage organs thereof accumulate tandem repeated GLP-1 derivatives cleavable with intestinal digestive enzyme to monomeric molecules and are produced by methods comprising: integrating into vectors linked DNAs which comprise tandem repeated DNAs encoding the GLP-1 derivative with trypsin resistance in which the amino acid in the 26th position is Gln, the amino acid in the 34th position is Asn or Asp, and C-terminal consists of Arg or Lys to produce monomeric molecules; introducing the vectors into plant cells; and redifferentiating the obtained transformants. The edible transgenic plants and plant storage organs are useful for treating diabetes and can be ingested by diabetic patients.