The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 24, 2011

Filed:

Aug. 23, 2007
Applicants:

Matthew G. Bursavich, Tuckahoe, NY (US);

Sabrina Lombardi, Wilton, CT (US);

Adam M. Gilbert, Congers, NY (US);

Leif Mark Laakso, Chester, NY (US);

Gulnaz Khafizova, West Nyack, NY (US);

David Brian How, Nyack, NY (US);

Joshua James Sabatini, White Plains, NY (US);

Phaik-eng Sum, Pomona, NY (US);

Jeremy Clemens, New City, NY (US);

Inventors:

Matthew G. Bursavich, Tuckahoe, NY (US);

Sabrina Lombardi, Wilton, CT (US);

Adam M. Gilbert, Congers, NY (US);

Leif Mark Laakso, Chester, NY (US);

Gulnaz Khafizova, West Nyack, NY (US);

David Brian How, Nyack, NY (US);

Joshua James Sabatini, White Plains, NY (US);

Phaik-Eng Sum, Pomona, NY (US);

Jeremy Clemens, New City, NY (US);

Assignee:

Wyeth LLC, Madison, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 215/04 (2006.01); A61K 31/04 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to 8-Hydroxyquinoline Compounds; compositions comprising an 8-Hydroxyquinoline Compound; and methods for treating or preventing a metalloproteinase-related disorder, such as, an arthritic disorder, osteoarthritis, malignant neoplasm, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, atherosclerosis, age-related macular degeneration, myocardial infarction, a corneal ulceration, an ocular surface disease, hepatitis, an aortic aneurysm, tendonitis, a central nervous system disorder, abnormal wound healing, angiogenesis, restenosis, cirrhosis, multiple sclerosis, glomerulonephritis, graft versus host disease, diabetes, an inflammatory bowel disease, shock, invertebral disc degeneration, stroke, osteopenia or a periodontal disease or comprising administering an effective dose of an 8-Hydroxyquinoline Compound to a mammal in need thereof.


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