The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 24, 2011
Filed:
Jan. 06, 2004
Rene S. Hubert, Los Angeles, CA (US);
Arthur B. Raitano, Los Angeles, CA (US);
Douglas Saffran, Encinitas, CA (US);
Daniel E. H. Afar, Brisbane, CA (US);
Steven Chappell Mitchell, Gurnee, IL (US);
Mary Faris, Los Angeles, CA (US);
Aya Jakobovits, Beverly Hills, CA (US);
Rene S. Hubert, Los Angeles, CA (US);
Arthur B. Raitano, Los Angeles, CA (US);
Douglas Saffran, Encinitas, CA (US);
Daniel E. H. Afar, Brisbane, CA (US);
Steven Chappell Mitchell, Gurnee, IL (US);
Mary Faris, Los Angeles, CA (US);
Aya Jakobovits, Beverly Hills, CA (US);
Agensys, Inc., Santa Monica, CA (US);
Abstract
Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed 'STEAP' (Six Transmembrane Epithelial Antigen of the Prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high'degree of structural conservation among them but show no significant structural homology to any known human proteins. STEAP-2 is a 454 amino acid protein characterized by a predicted molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a 'serpentine' manner into three extracellular and two intracellular loops.