The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 17, 2011
Filed:
Feb. 10, 2005
Mitsuo Sekine, Yokohama, JP;
Kohji Seio, Yokohama, JP;
Akihiro Ohkubo, Machida, JP;
Japan Science and Technology Agency, Kawaguchi-shi, JP;
Abstract
Methods of synthesizing nucleic acid oligomers on a solid-phase support having a 3'-end nucleoside unit introduced thereon-as represented by formula II: wherein of formula II represents a 2′-deoxyribonucleoside or its N-protected derivative, the substituent —O—(R)Si(R)—(CHR)—(CH)—O—P(OR)XO)—(CH)is attached at the 3′ position of the sugar moiety of the nucleoside substituent; each of Rand Ris an alkyl or optionally substituted aryl group, wherein the optionally substituted aryl group has a substituent selected from the group consisting of Calkyl, nitro, cyano, halo and methoxyl; Ris a protecting group; X is S or O; Ris H or 4,4′-dimethoxytrityl; each n is an integer of from 1 to 5; and the solid-phase support has hydroxyl groups on its surface.