The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2011
Filed:
Sep. 22, 2008
Hua Wang, Boise, ID (US);
Denise Wingett, Boise, ID (US);
Kevin Feris, Boise, ID (US);
Madhusudan R Kongara, Boise, ID (US);
Alex Punnoose, Boise, ID (US);
Hua Wang, Boise, ID (US);
Denise Wingett, Boise, ID (US);
Kevin Feris, Boise, ID (US);
Madhusudan R Kongara, Boise, ID (US);
Alex Punnoose, Boise, ID (US);
Boise State University, Boise, ID (US);
Abstract
Multifunctional 'smart' nanostructures are disclosed that include fluorescein isothiocyanate (FITC)-encapsulated SiOcore-shell particles with a nanoscale ZnO finishing layer, wherein an outer ZnO layer is formed on the SiO-FITC core. These ˜200 nm sized particles showed promise toward cell imaging and cellular uptake studies using the bacteriumand Jurkat cancer cells, respectively. The FITC encapsulated ZnO particles demonstrated excellent selectivity in preferentially killing Jurkat cancer cells with minimal toxicity to normal primary immune cells (18% and 75% viability remaining, respectively, after exposure to 60 μg/mL) and inhibited the growth of both gram-positive and gram-negative bacteria at concentrations ≧250-500 μg/mL (forand, respectively). These results indicate that the FITC encapsulated multifunctional particles with nanoscale ZnO surface layer can be used as smart nanostructures for particle tracking, cell imaging, antibacterial treatments and cancer therapy.